CMAP x GTEx - Sex-Biased Drug Response Explorer
How do male and female cells differ when exposed to the same drug? This explores per-lineage GSEA results (CMAP/LINCS 2020 vs GTEx v8) from Project 59.
What is this?
Drug trials usually report a single average effect. But male and female cells often respond to the same drug differently. This app explores how a drug's sex-specific effect on gene expression lines up with a tissue's natural sex biology, using per-lineage GSEA on CMAP/LINCS 2020 drug signatures vs GTEx v8 sex-biased genes.
How to use it
- Use the Select a drug dropdown below. Pick All to see every hit, or type a drug name (e.g. tozasertib) to focus on one.
- Read the table: each row is a drug-tissue pair where the drug significantly overlaps that tissue's sex-biased genes (FDR < 0.05).
- Read the bar chart: it shows the NES (enrichment score) per hit.
How to read the numbers
- Green bar (NES above 0) -> effect leans male-biased
- Red bar (NES below 0) -> effect leans female-biased
- FDR = reliability; smaller is stronger (all shown are < 0.05)
Categories
- A - drug hits sex-biased genes in its OWN tissue -> real signal (tozasertib, lapatinib, vorinostat)
- B - drug hits sex-biased genes in a DIFFERENT tissue -> off-target candidate (23 drugs)
- C - no significant sex-specific effect (not shown here)
Select a drug
Results
Research output - Project 59, Fatima Fellowship 2026. Data: CMAP/LINCS 2020 and GTEx v8 (public). For scientific and educational use only; not medical advice.